#Automute protein how to#

The more email messages I received in Fleep, however, the more I felt the need to enable Automute. I’ll be honest, I was skeptical about the Automute feature when we first discussed the concept. What changes once you start using Automute in Fleep? No more unnecessary, low-priority distractions via email. There may be a few useful email conversations in there, but it is more likely that the conversations in there are newsletters you did not know you signed up for, sales pitches you did not ask for and other email messages that do not require your urgent response.

Third, try to review the conversations under the Muted label 1-2 times a day at the most.

The unread label for the Muted label is intentionally subtle so you wouldn’t feel any guilt for the number there. This is a trick we learned from our CEO – in this way, you will not forget to take a look at the muted conversations every now and then.

Secondly, you may want to drag the Muted label above Recent on the left pane and collapse it.

First of all you’ll have to configure it in the Account preferences, as it is turned off by default.

#Automute protein how to#

How to make the most out of Automute in Fleep? Note that the “stranger(s)” in the new conversation will be added to your contacts only if you reply into that new conversation or when someone among your contacts adds you to a conversation with the “stranger(s)”. More specifically, if the incoming email message was sent by someone who is not in your contacts, the newly created conversation is automatically muted. people who are not in your contact list) do not get your attention unless you want to give them your attention. The goal of Automute is to make sure conversations created by “strangers” (i.e. You will not receive any notifications about them, but the conversations will remain unread until you can read them at your own convenience.

If Automute is enabled, all of the automatically muted incoming email conversations will be visible under the Muted label.

This is why we have built the Automute feature - the option to have Fleep automatically mute all incoming emails that are sent from a new email address (that is, an email address that is not among your Fleep contacts). Sometimes, they’re worth your attention – other times, not so much. Whoever has been able to find out your email address can try to get your attention. Implementation of the random forest algorithm, for classifying mutant activity as either unaffected or affected relative to the native protein, yields 84% accuracy based on tenfold cross-validation.One of the reasons why email tends to be a drain on your productivity is that anyone can attempt to reach you via email. The proteins are diverse with respect to host organism (viral, bacterial, human) and function (enzymatic, nucleic acid binding, signaling), the structures span all four major SCOP classifications, and the mutations occur at positions well distributed throughout the seven structures. A computational mutagenesis methodology founded upon a structure-dependent and knowledge-based four-body statistical potential is utilized in generating feature vectors that characterize over 8500 individual amino acid substitutions occurring in seven proteins, each mutant having been experimentally ascertained for its relative effect on native protein activity.